J. Craig Venter’s startup, Human Longevity Inc., partners with Discovery Health to offer DNA sequencing for $250, aiming to create a vast genomic database. This initiative is designed to enhance understanding of genetic influences on health while promoting wellness through affordable genetic testing. Despite potential challenges, the project could significantly impact personalized medicine.
J. Craig Venter, a key figure in genomics, is partnering with a South African health insurer to provide DNA sequencing services for $250, a significant reduction from traditional costs. Through his startup, Human Longevity Inc. (HLI), Venter’s aim is to sequence important medically relevant genes for clients, thereby initiating a new wave in consumer access to genomic data.
HLI, operating one of the largest DNA sequencing labs globally, intends to compile a vast database of one million genomes within four years. An agreement with Discovery Health allows for the partial decoding of clients’ genomes, with insights delivered alongside comprehensive health reports. This initiative represents a pioneering collaboration with an insurer to make genetic information commercially accessible.
Jonathan Broomberg, CEO of Discovery Health, articulates the dual goal of promoting wellness while managing costs. Clients will pay half the sequencing fee, with the remaining cost subsidized by Discovery. Gene data will be dispatched to healthcare professionals rather than directly to individuals, emphasizing secure and accountable handling of sensitive information.
The genomic information gathered will focus on exomes, which comprise vital genes associated with serious health risks, including cancers and heart diseases. Broomberg expresses optimism regarding public adoption of this service despite concerns about potential reluctance from clients to learn about their genetic predispositions.
HLI envisions creating a comprehensive genetic and medical database, seeking to enhance understanding of the relationship between genes and health outcomes. Venter asserts that current knowledge represents a fraction of the useful information contained within the human genome, advocating for broader genetic research.
Aside from commercial endeavors, HLI is accumulating genomic data through collaborations with organizations like Genentech and Cleveland Clinic, which is crucial for ongoing research. Broomberg adds the importance of integrating African gene data into global research agendas, which have historically lacked such diversity.
Venter aims to leverage the large sample size to elucidate genetic influences on traits, such as height and other health risks. The U.S. government’s precision-medicine initiative is similarly ambitious but may not match Venter’s pace. HLI employs advanced machine learning techniques to analyze genomic data, progressing towards predicting traits like physical appearance from genetic codes.
To further these aims, HLI will soon launch a “health nucleus” providing extensive genetic analyses for high-profile clients, including executives and athletes. The center promises a wide range of services, including comprehensive health assessments and continuous updates on genetic findings. However, the costs associated with this program are substantial, priced at $25,000 per individual.
While Venter’s scientific credentials are noteworthy, experts caution that his organization lacks experience in patient care. Charis Eng from the Cleveland Clinic emphasizes the necessity of ensuring that services are both medically and scientifically sound. Venter recognizes the necessity of securing substantial funding, considering the high costs associated with large-scale genome sequencing.
J. Craig Venter’s initiative to offer affordable DNA sequencing through collaboration with Discovery Health marks a significant advancement in consumer access to genetic data. By aiming to create a vast genomic database, HLI intends to deepen understanding of genetic influences on health. Despite challenges regarding public acceptance and patient care experience, this project could revolutionize personalized medicine and wellness programs.
Original Source: www.technologyreview.com
